==Dietary fiber inulin propionate ester (IPE) designed to slow weight gain receives novel food approval

Inulin-propionate ester (IPE) is a novel dietary fiber compound created by bonding propionic acid to inulin. It passes through the upper digestive tract and is fermented by gut bacteria in the colon, where the released propionate stimulates appetite-regulating hormones (GLP-1 and PYY), helping you feel fuller longerWhat is IPE?

• IPE (inulin propionate ester) is a synthesized dietary fiber developed by researchers at Imperial College London and the University of Glasgow (including SUERC).
• It combines inulin (a natural fiber from sources like chicory) with propionic acid (a short-chain fatty acid produced by gut microbes when they ferment fiber).
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• The goal is to amplify the benefits of high-fiber diets by promoting feelings of fullness (satiety), reducing appetite, and helping curb the small daily calorie surpluses that lead to long-term weight gain. 

 Approval Details

• It received a positive safety opinion from the European Food Safety Authority (EFSA) after review of toxicological, nutritional, and microbiological data.
• The European Commission granted final authorization, adding IPE to the EU List of Authorized Novel Foods (around early July 2026).
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• This followed years of regulatory work (about six years of uncertainty) and builds on earlier randomized controlled trials showing benefits at doses around 10 grams per day. 

High-fiber diets are linked to better satiety, weight management, and metabolic health. IPE aims to deliver these effects more efficiently:

• It targets appetite regulation via gut mechanisms.
• Trials indicated it can help prevent weight gain by making people feel fuller longer.
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• It is positioned as a tool for satiety-led foods (e.g., potentially added to bread, cereals, or other everyday products) to support gradual weight management before more intensive interventions. 

==Peptides for longevity and anti-aging

Peptides are short chains of amino acids that your body naturally produces. They act as signaling molecules to help regulate things like cellular repair, hormone release, and energy production.

As you age, some of these signals naturally decline. Longevity peptides are designed to support the specific pathways that tend to slow down over time:

• Growth hormone secretion
• Mitochondrial energy production
• Your body's natural antioxidant defenses

For many people, that means more targeted support for energy, sleep quality, recovery, and body composition. Because these therapies work at a cellular and hormonal level, they're prescribed by licensed providers and compounded at regulated pharmacies.  

What is NAD+?

• Essential for cellular energy production and metabolic function
• Plays a role in brain health and cellular repair
• Declines over time, which may impact how you feel day to day

What is sermorelin?

• Supports your body’s natural growth hormone production
• Used for recovery, sleep, and body composition
• Designed to work with your biology, not override it

What is glutathione?

• Promotes overall cellular health and immune resilience
• Delivered directly into the bloodstream to support detoxification and reduce oxidative stress
• Your body's master antioxidant, produced naturally but depleted by stress, aging, and everyday life

Is Ozempic a peptide?

Yes, Ozempic is a peptide. 

Specifically, it is a synthetic glucagon-like peptide-1 (GLP-1) receptor agonist made from a chain of 31 amino acids. 

By classifying as a peptide rather than a biologic (which requires more than 40 amino acids), it is regulated by the FDA like most standard, small-molecule medications.

Olive oil, nuts better than drugs for heart disease

Early results from a Spanish cohort study featuring 7500 people with heart disease risk have found Mediterranean diets high in virgin olive oil (VOO) and nuts are more effective in reducing heart disease event likelihood than drug treatments.

Unlike refined oils, fresh-pressed EVOO is loaded with high levels of polyphenols (antioxidants) and anti-inflammatory compounds that:
 

• Protect Your Heart: Dramatically reduces inflammation and lowers "bad" cholesterol.
• Boost Brain Health: May help protect against dementia and cognitive decline.
• Act Like Natural Medicine: Contains oleocanthal, which provides anti-inflammatory benefits similar to ibuprofen.

The team of Spanish researchers published initial findings in the trial that is due to complete next year in
Atherosclerosis, reporting significant improvements in groups eating traditional Mediterranean diets plus VOO or nuts, compared to those on a low-fat diet.

Among the over-55s artery thickness was lower in the VOO and nut groups but only among those who already had somewhat thickened arteries.

One of the researchers, Dr Miguel Angel Martínez-González, from the Department of Preventative Medicine at the University of Navarra, said the findings emphasised the value of dietary versus pharma interventions in
controlling cardiovascular event likelihood.

They showed that, “a modification in the entire diet pattern managed to achieve, in just one year, results that
pharmaceutical drugs did not – even after two years of treatment.”

However, “This improvement was not observed amongst those who did not have thickening of the artery wall at the start of the study.”

The study places each volunteer in one of three groups following a Mediterranean diet with the VOO group
receiving 15 litres of virgin olive oil per three months, a nut group given 30g a day of walnuts, almonds and hazelnuts, and a third group given instructions and material to follow a low-fat diet.

“We thus observed who had suffered the greatest thickening of this layer — due to arteriosclerosis — a significant improvement and regression of lesions having taken place in those cases that had followed a
Mediterranean diet enriched with virgin olive oil or nuts,” said Dr Ana Sánchez-Tainta, also from the University of Navarra.

The results showed the nut and VOO groups after three months had improved adolipoprotein ratios that delivered lower heart disease risk for both men and women.